Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
Titration of the KLF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 20-53 from the human protein was used as the immunogen for this KLF4 antibody.
Aliquot the KLF4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
