The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [RefSeq]

Optimal dilution of the Keratin 8 antibody should be determined by the researcher.

A synthetic peptide specific to human Cytokeratin 8 / KRT8 was used as the immunogen for the Keratin 8 antibody.

Store the Keratin 8 antibody at -20oC.