Pre-mRNA splicing occurs in two sequential transesterification steps. "Pre-mRNA-processing factor 17," also called EHB3, PRP17, PRPF17 and CDC40, is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [RefSeq]

Optimal dilution of the CDC40 antibody should be determined by the researcher.

A synthetic peptide specific to human CDC40 was used as the immunogen for the CDC40 antibody.

Store the CDC40 antibody at -20oC.