Tyrosine-protein kinase JAK2 is a non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. [UniProt]

Optimal dilution of the JAK2 antibody should be determined by the researcher.

A synthetic peptide specific to human JAK2 was used as the immunogen for the JAK2 antibody.

Store the JAK2 antibody at -20oC.