AIF1 (Allograft inflammatory factor 1), also called IBA1 (Ionized calcium-binding adapter molecule 1) is a cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1/IBA1, containing two EF domains, is induced by cytokines and Interferons. In an unstimulated state, it colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding the protein resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).

Titering of the AIF1 antibody may be required for optimal performance.

A portion of amino acids 1-146 from the human protein was used as the immunogen for the AIF1 antibody.

Store the AIF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).