Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Optimal dilution of the GITR antibody should be determined by the researcher.

A recombinant human protein corresponding to amino acids Q26-P162 was used as the immunogen for the TNFRSF18 antibody.

After reconstitution, the GITR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.