CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the CD11b antibody to be titered up or down for optimal performance.

Recombinant human CD11b/ITGAM protein was used as the immunogen for this antibody.

Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Granulocyte marker