The protein encoded by this gene is a member of theintercellular adhesion molecule (ICAM) family. All ICAM proteinsare type I transmembrane glycoproteins, contain 2-9immunoglobulin-like C2-type domains, and bind to the leukocyteadhesion LFA-1 protein. This protein may play a role in lymphocyterecirculation by blocking LFA-1-dependent cell adhesion. Itmediates adhesive interactions important for antigen-specificimmune response, NK-cell mediated clearance, lymphocyterecirculation, and other cellular interactions important for immuneresponse and surveillance. Several transcript variants encoding thesame protein have been found for this gene.
Titration of the ICAM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 191-218 from the human protein was used as the immunogen for this ICAM2 antibody.
Aliquot the ICAM2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
