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当前位置: 首页 > 产品中心 > peptide > NSJ Bio/NRF-2 Antibody / NFE2L2 (RQ5744)/100 ug/RQ5744
商品详细NSJ Bio/NRF-2 Antibody / NFE2L2 (RQ5744)/100 ug/RQ5744
NSJ Bio/NRF-2 Antibody / NFE2L2 (RQ5744)/100 ug/RQ5744
NSJ Bio/NRF-2 Antibody / NFE2L2 (RQ5744)/100 ug/RQ5744
商品编号: RQ5744
品牌: NSJBioreagents
市场价: ¥8380.00
美元价: 6704.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description

NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-RELATED TRANSCRIPTION FACTOR 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas(G12D) and BRaf(V619E), and in human pancreatic cancer.

Application Notes

Optimal dilution of the NRF-2 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids R34-N605) was used as the immunogen for the NRF-2 antibody.

Storage

After reconstitution, the NRF-2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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