Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Optimal dilution of the Beta Amyloid antibody should be determined by the researcher.

A portion of amino acids 578-680 from the human protein was used as the immunogen for the Beta Amyloid antibody.

Store the Beta Amyloid antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).