This recombinant rabbit monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

Optimal dilution of the recombinant Synaptophysin antibody should be determined by the researcher.

A portion of amino acids 224-313 from the human protein was used as the immunogen for the recombinant Synaptophysin antibody.

Store the recombinant Synaptophysin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).