Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewings Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

Optimal dilution of the FLI1 antibody should be determined by the researcher.

A portion of amino acids 107-261 from the human protein was used as the immunogen for the FLI1 antibody.

Store the FLI1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).