ETS1 proto-oncogene is an important transcription factor that plays a role in cell proliferation and differentiation. ETS1 is related to the growth of carcinoma cells by its regulation of the transcription of matrix metalloproteinases and urokinase-type plasminogen activator.The processes of tumor invasion and metastasis depend on the increased proteolytic activity of the invading tumor cells that may involve matrix metalloproteinases, cathepsins B and D and plasminogen activator in the metastatic cascade. ETS1 is preferentially expressed in lymphoid cells, where it is essential for the maintenance of the normal pool of resting T and B cells.ETS1 expression level and distribution are differentially controlled in resting, activated and apoptotic lymphocytes.

Optimal dilution of the ETS1 antibody should be determined by the researcher.

A recombinant human partial protein (amino acids 137-230) was used as the immunogen for the ETS1 antibody.

Store the ETS1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).