Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Optimal dilution of the Langerin antibody should be determined by the researcher.

A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.

Store the Langerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).