Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer"s disease.

Optimal dilution of the CTSD antibody should be determined by the researcher.

A recombinant human partial protein (amino acids 104-250) was used as the immunogen of the CTSD antibody.

Store the CTSD antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).