The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents.

Optimal dilution of the p73 antibody should be determined by the researcher.

A recombinant full-length human protein was used as the immunogen for this p73 antibody.

Store the p73 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).