The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression.

Optimal dilution of the Uroplakin 1A antibody should be determined by the researcher.

Amino acids 114-173 were used as the immunogen for the Uroplakin 1A antibody.

Store the Uroplakin 1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).