PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.

Optimal dilution of the PD-L1 antibody should be determined by the researcher.

A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody.

Store the PD-L1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).