Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

Optimal dilution of the recombinant SDHB antibody should be determined by the researcher.

A synthetic peptide specific to human SDHB was used as the immunogen for the recombinant SDHB antibody.

Aliquot the recombinant SDHB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.