Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Two molecules of each of the four core histones (H2A,H2B, H3, and H4) form an octamer, around which approximately 146 bpof DNA is wrapped in repeating units, called nucleosomes. Thelinker histone, H1, interacts with linker DNA between nucleosomesand functions in the compaction of chromatin into higher orderstructures. This gene is intronless and encodes a member of thehistone H2B family. Transcripts from this gene lack polyA tails butinstead contain a palindromic termination element. This gene isfound in the histone microcluster on chromosome 6p21.33. [providedby RefSeq].

The stated application concentrations are suggested starting points. Titration of the HIST1H2BJ antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 57-86 from the human protein was used as the immunogen for the HIST1H2BJ antibody.

Aliquot the HIST1H2BJ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.