SIM1 and SIM2 genes are Drosophila single-minded (sim)gene homologs.SIM1 transcript was detected only in fetal kidneyout of various adult and fetal tissues tested.Since the sim geneplays an important role in Drosophila development and has peaklevels of expression during the period of neurogenesis,it wasproposed that the human SIM gene is a candidate for involvement incertain dysmorphic features (particularly the facial and skullcharacteristics), abnormalities of brain development, and/or mentalretardation of Down syndrome.
The stated application concentrations are suggested starting points. Titration of the Single-minded homolog 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1-30 from the human protein was used as the immunogen for the Single-minded homolog 1 antibody.
Aliquot the Single-minded homolog 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
