p19 / Cyclin-dependent kinase 4 inhibitor D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.

The stated application concentrations are suggested starting points. Titration of the CDKN2D antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 15-43 from the human protein was used as the immunogen for the CDKN2D antibody.

Aliquot the CDKN2D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.