The inhibin beta B subunit joins the alpha subunit toform a pituitary FSH secretion inhibitor.Inhibin has been shownto regulate gonadal stromal cell proliferation negatively and tohave tumour-suppressor activity.In addition, serum levels ofinhibin have been shown to reflect the size of granulosa-celltumors and can therefore be used as a marker for primary as well asrecurrent disease. Because expression in gonadal and variousextragonadal tissues may vary severalfold in a tissue-specificfashion, it is proposed that inhibin may be both agrowth/differentiation factor and a hormone.Furthermore, the betaB subunit forms a homodimer, activin B, and also joins with thebeta A subunit to form a heterodimer, activin AB, both of whichstimulate FSH secretion.

The stated application concentrations are suggested starting points. Titration of the Inhibin beta B chain antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 369-397 from the human protein was used as the immunogen for the Inhibin beta B chain antibody.

Aliquot the Inhibin beta B chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.