This gene encodes a retina-specific guanylate cyclase,which is a member of the membrane guanylyl cyclase family. Likeother membrane guanylyl cyclases, this enzyme has a hydrophobicamino-terminal signal sequence followed by a large extracellulardomain, a single membrane spanning domain, a kinase homologydomain, and a guanylyl cyclase catalytic domain. In contrast toother membrane guanylyl cyclases, this enzyme is not activated bynatriuretic peptides. Mutations in this gene result in Lebercongenital amaurosis and cone-rod dystrophy-6 diseases. [providedby RefSeq].

The stated application concentrations are suggested starting points. Titration of the Retinal guanylyl cyclase 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 540-570 from the human protein was used as the immunogen for the Retinal guanylyl cyclase 1 antibody.

Aliquot the Retinal guanylyl cyclase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.