The protein encoded by this gene is a member of thechromogranin/secretogranin family of neuroendocrine secretoryproteins. It is found in secretory vesicles of neurons andendocrine cells. This gene product is a precursor to threebiologically active peptides; vasostatin, pancreastatin, andparastatin. These peptides act as autocrine or paracrine negativemodulators of the neuroendocrine system. Other peptides, includingchromostatin, beta-granin, WE-14 and GE-25, are also derived fromthe full-length protein. However, biological activities for thesemolecules have not been shown.
The stated application concentrations are suggested starting points. Titration of the CMGA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 376-404 from the human protein was used as the immunogen for the CMGA antibody.
Aliquot the CMGA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
