Members of arrestin/beta-arrestin protein family arethought to participate in agonist-mediated desensitization ofG-protein-coupled receptors and cause specific dampening ofcellular responses to stimuli such as hormones, neurotransmitters,or sensory signals.Arrestin beta 1 is a cytosolic protein andacts as a cofactor in the beta-adrenergic receptor kinase (BARK)mediated desensitization of beta-adrenergic receptors.Besides thecentral nervous system, it is expressed at high levels inperipheral blood leukocytes, and thus the BARK/beta-arrestin systemis believed to play a major role in regulating receptor-mediatedimmune functions.Alternatively spliced transcripts encodingdifferent isoforms of arrestin beta 1 have been described, however,their exact functions are not known.
The stated application concentrations are suggested starting points. Titration of the ARRB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 336-363 from the human protein was used as the immunogen for the ARRB1 antibody.
Aliquot the ARRB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
