The protein encoded by this gene belongs to thedystrobrevin subfamily of the dystrophin family. This protein is acomponent of the dystrophin-associated protein complex (DPC), whichconsists of dystrophin and several integral and peripheral membraneproteins, including dystroglycans, sarcoglycans, syntrophins andalpha- and beta-dystrobrevin. The DPC localizes to the sarcolemmaand its disruption is associated with various forms of musculardystrophy. Mutations in this gene are associated with leftventricular noncompaction with congenital heart defects. Multiplealternatively spliced transcript variants encoding differentisoforms have been identified for this gene.
The stated application concentrations are suggested starting points. Titration of the Dystrobrevin alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 692-721 from the human protein was used as the immunogen for the Dystrobrevin alpha antibody.
Aliquot the Dystrobrevin alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
