This gene encodes a member of the serpin superfamily ofserine proteinase inhibitors. The protein is primarily secreted byaxons in the brain, and preferentially reacts with and inhibitstissue-type plasminogen activator. It is thought to play a role inthe regulation of axonal growth and the development of synapticplasticity. Mutations in this gene result in familialencephalopathy with neuroserpin inclusion bodies (FENIB), which isa dominantly inherited form of familial encephalopathy and epilepsycharacterized by the accumulation of mutant neuroserpin polymers.Multiple alternatively spliced variants, encoding the same protein,have been identified.

The stated application concentrations are suggested starting points. Titration of the SERPINI1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 19-45 from the human protein was used as the immunogen for the SERPINI1 antibody.

Aliquot the SERPINI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.