The protein encoded by this gene is a member of a familyof proteins that inhibits apoptosis by binding to tumor necrosisfactor receptor-associated factors TRAF1 and TRAF2, probably byinterfering with activation of ICE-like proteases. The encodedprotein inhibits apoptosis induced by serum deprivation but doesnot affect apoptosis resulting from exposure to menadione, a potentinducer of free radicals. The amino acid sequence predicts threebaculovirus IAP repeat domains and a ring finger domain. Transcriptvariants encoding the same isoform have been identified. [providedby RefSeq].

The stated application concentrations are suggested starting points. Titration of the BIRC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 59-88 from the human protein was used as the immunogen for the BIRC3 antibody.

Aliquot the BIRC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.