This gene encodes N-acetylgalactosamine-6-sulfatase whichis a lysosomal exohydrolase required for the degradation of theglycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate.Sequence alterations including point, missense and nonsensemutations, as well as those that affect splicing, result in adeficiency of this enzyme. Deficiencies of this enzyme lead toMorquio A syndrome, a lysosomal storage disorder. [provided byRefSeq].
The stated application concentrations are suggested starting points. Titration of the GALNS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 236-263 from the human protein was used as the immunogen for the GALNS antibody.
Aliquot the GALNS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
