This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3" UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

The stated application concentrations are suggested starting points. Titration of the GPX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 93-123 from the human protein was used as the immunogen for the GPX3 antibody.

Aliquot the GPX3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.