This gene was identified by its translocation in a case ofmucosa-associated lymphoid tissue (MALT) lymphoma. The proteinencoded by this gene contains a caspase recruitment domain (CARD),and has been shown to induce apoptosis and to activate NF-kappaB.This protein is reported to interact with other CARD domaincontaining proteins including CARD9, 10, 11 and 14, which arethought to function as upstream regulators in NF-kappaB signaling.This protein is found to form a complex with MALT1, a proteinencoded by another gene known to be translocated in MALT lymphoma.MALT1 and this protein are thought to synergize in the activationof NF-kappaB, and the deregulation of either of them may contributeto the same pathogenetic process that leads to the malignancy.

The stated application concentrations are suggested starting points. Titration of the BCL10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 24-51 from the human protein was used as the immunogen for the BCL10 antibody.

Aliquot the BCL10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.