This gene encodes the D2 subtype of the dopamine receptor.This G-protein coupled receptor inhibits adenylyl cyclase activity.A missense mutation in this gene causes myoclonus dystonia; othermutations have been associated with schizophrenia. Alternativesplicing of this gene results in two transcript variants encodingdifferent isoforms. A third variant has been described, but it hasnot been determined whether this form is normal or due to aberrantsplicing.
The stated application concentrations are suggested starting points. Titration of the DRD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 307-336 from the human protein were used as the immunogen for the DRD2 antibody.
Aliquot the DRD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
