This gene belongs to the tumor necrosis factor receptorsuperfamily. The encoded protein is postulated to play a regulatoryrole in suppressing FasL- and LIGHT-mediated cell death. It acts asa decoy receptor that competes with death receptors for ligandbinding. Overexpression of this gene has been noted ingastrointestinal tract tumors, and it is located in a gene-richcluster on chromosome 20, with other potentially tumor-relatedgenes. Two transcript variants encoding the same isoform, butdiffering in the 5" UTR, have been observed for this gene.

The stated application concentrations are suggested starting points. Titration of the DcR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 22-48 from the human protein was used as the immunogen for the DcR3 antibody.

Aliquot the DcR3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.