PTP4A2 belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.

The stated application concentrations are suggested starting points. Titration of the PTP4A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 32-59 from the human protein was used as the immunogen for the PTP4A2 antibody.

Aliquot the PTP4A2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.