DEK is a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases.
The stated application concentrations are suggested starting points. Titration of the DEK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 336-364 from the human protein was used as the immunogen for the DEK antibody.
Aliquot the DEK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
