The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor.Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity.In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells.Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

The stated application concentrations are suggested starting points. Titration of the Inhibin alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 79-108 from the human protein was used as the immunogen for the Inhibin alpha antibody.

Aliquot the Inhibin alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.