The TPM4 gene encodes a member of the tropomyosin family ofactin-binding proteins involved in the contractile system ofstriated and smooth muscles and the cytoskeleton of non-musclecells. Tropomyosins are dimers of coiled-coil proteins thatpolymerize end-to-end along the major groove in most actinfilaments. They provide stability to the filaments and regulateaccess of other actin-binding proteins. In muscle cells, theyregulate muscle contraction by controlling the binding of myosinheads to the actin filament. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].

The stated application concentrations are suggested starting points. Titration of the Tropomyosin 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 26-54 from the human protein was used as the immunogen for the Tropomyosin 4 antibody.

Aliquot the Tropomyosin 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.