This gene is a member of the visinin/recoverin subfamilyof neuronal calcium sensor proteins. The encoded protein isstrongly expressed in granule cells of the cerebellum where itassociates with membranes in a calcium-dependent manner andmodulates intracellular signaling pathways of the central nervoussystem by directly or indirectly regulating the activity ofadenylyl cyclase. Alternatively spliced transcript variants havebeen observed, but their full-length nature has not beendetermined.
The stated application concentrations are suggested starting points. Titration of the VSNL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 47-75 from the human protein was used as the immunogen for the VSNL1 antibody.
Aliquot the VSNL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
