Prostaglandin-endoperoxide synthase (PTGS), also known ascyclooxygenase, is the key enzyme in prostaglandin biosynthesis,and acts both as a dioxygenase and as a peroxidase. There are twoisozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2,which differ in their regulation of expression and tissuedistribution. This gene encodes the inducible isozyme. It isregulated by specific stimulatory events, suggesting that it isresponsible for the prostanoid biosynthesis involved ininflammation and mitogenesis.
The stated application concentrations are suggested starting points. Titration of the Cyclooxygenase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 363-391 from the human protein was used as the immunogen for the Cyclooxygenase 2 antibody.
Aliquot the Cyclooxygenase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
