This gene is similar to the Drosophila additional sexcombs gene, which encodes a chromatin-binding protein required fornormal determination of segment identity in the developing embryo.The protein is a member of the Polycomb group of proteins, whichare necessary for the maintenance of stable repression of homeoticand other loci. The protein is thought to disrupt chromatin inlocalized areas, enhancing transcription of certain genes whilerepressing the transcription of other genes. The protein encoded bythis gene functions as a ligand-dependent co-activator for retinoicacid receptor in cooperation with nuclear receptor coactivator 1.Mutations in this gene are associated with myelodysplasticsyndromes and chronic myelomonocytic leukemia. Alternative splicingresults in multiple transcript variants.
The stated application concentrations are suggested starting points. Titration of the Additional sex combs-like protein 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 521-549 from the human protein was used as the immunogen for the Additional sex combs-like protein 1 antibody.
Aliquot the Additional sex combs-like protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
