This gene is a member of the Regulator of ComplementActivation (RCA) gene cluster and encodes a protein with twentyshort concensus repeat (SCR) domains. This protein is secreted intothe bloodstream and has an essential role in the regulation ofcomplement activation, restricting this innate defense mechanism tomicrobial infections. Mutations in this gene have been associatedwith hemolytic-uremic syndrome (HUS) and chronic hypocomplementemicnephropathy. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized.

The stated application concentrations are suggested starting points. Titration of the Complement factor H antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 751-780 from the human protein was used as the immunogen for the Complement factor H antibody.

Aliquot the Complement factor H antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.