The protein encoded by this gene is a type I transmembraneprotein identified as a subunit of the interleukin 12 receptorcomplex. The coexpression of this and IL12RB1 proteins was shown tolead to the formation of high-affinity IL12 binding sites andreconstitution of IL12 dependent signaling. The expression of thisgene is up-regulated by interferon gamma in Th1 cells, and plays arole in Th1 cell differentiation. The up-regulation of this gene isfound to be associated with a number of infectious diseases, suchas Crohn"s disease and leprosy, which is thought to contribute tothe inflammatory response and host defense.

The stated application concentrations are suggested starting points. Titration of the IL12RB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 756-783 from the human protein was used as the immunogen for the IL12RB2 antibody.

Aliquot the IL12RB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.