This gene represents a nuclear retinoic acid receptor. Theencoded protein, retinoic acid receptor alpha, regulatestranscription in a ligand-dependent manner. This gene has beenimplicated in regulation of development, differentiation,apoptosis, granulopoeisis, and transcription of clock genes.Translocations between this locus and several other loci have beenassociated with acute promyelocytic leukemia. Alternatively splicedtranscript variants have been found for this locus.
The stated application concentrations are suggested starting points. Titration of the RAR alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 322-349 from the human protein were used as the immunogen for the RAR alpha antibody.
Aliquot the RAR alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
