The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98%, 98% and 87% amino acid identityto the mouse, rat and the xenopus Wnt5A protein, respectively. Theexperiments performed in Xenopus laevis embryos identified thathuman frizzled-5 (hFz5) is the receptor for the Wnt5A ligand andthe Wnt5A/hFz5 signaling mediates axis induction. [provided byRefSeq].
Titration of the WNT5A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 185-213 from the human protein was used as the immunogen for this WNT5A antibody.
Aliquot the WNT5A antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
