This gene encodes a member of the insulin family ofpolypeptide growth factors, which are involved in development andgrowth. It is an imprinted gene, expressed only from the paternalallele, and epigenetic changes at this locus are associated withWilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, andSilver-Russell syndrome. A read-through INS-IGF2 gene exists, whose5" region overlaps the INS gene and the 3" region overlaps thisgene. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.

Titration of the IGF2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 39-68 from the human protein was used as the immunogen for this IGF2 antibody.

Aliquot the IGF2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.