It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.

Optimal dilution of the recombinant c-Myc antibody should be determined by the researcher.

Amino acids 408-439 were used as the immunogen for the recombinant c-Myc antibody. The specific epitope has been localized to amino acids 410-419 (EQKLISEEDL).

Store the recombinant c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).