Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Optimal dilution of the ErbB2 antibody should be determined by the researcher.

Recombinant human protein was used as the immunogen for this ErbB2 antibody. Its epitope is localized in the extracellular domain.

Store the ErbB2 antibody at 2-8oC, protected from light.