This gene is a member of the STEAP family and encodes amulti-pass membrane protein that localizes to the Golgi complex,the plasma membrane, and the vesicular tubular structures in thecytosol. A highly similar protein in mouse has both ferrireductaseand cupric reductase activity, and stimulates the cellular uptakeof both iron and copper in vitro. Increased transcriptionalexpression of the human gene is associated with prostate cancerprogression. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized.
The stated application concentrations are suggested starting points. Titration of the STEA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 229-258 from the human protein was used as the immunogen for the STEA2 antibody.
Aliquot the STEA2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
