This gene encodes a member of a superfamily of divalentcation-dependent phosphodiesterases. The encoded protein associateswith CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptorassociated factors (TRAFs), and inhibits nuclear factor-kappa-Bactivation. This protein has sequence and structural similaritieswith APE1 endonuclease, which is involved in both DNA repair andthe activation of transcription factors.
The stated application concentrations are suggested starting points. Titration of the Tyrosyl-DNA phosphodiesterase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 246-272 from the human protein was used as the immunogen for the Tyrosyl-DNA phosphodiesterase 2 antibody.
Aliquot the Tyrosyl-DNA phosphodiesterase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
